Aryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: RESULTS(7)
Examination of FITC-lectin-, TOTO-3-, and Nile red-stained sperm by confocal microscopy revealed an intense acrosomal staining with FITC-lectin (green), nuclear staining with TOTO-3 (blue), and...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: RESULTS(8)
TEM of the tangential sections of sperm head confirmed the intactness of the plasma membrane and outer and inner acrosomal membranes of sperm exposed to vehicle (Fig. 5A”), WHI-05 (Fig. 5B”), and...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: RESULTS(9)
The mean sperm-zona binding ratio for control eggs coincubated with SYBR 14- and SYTO 17-labeled control sperm was 1.07. In contrast, the mean sperm-zona binding ratios for eggs coincubated with...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: RESULTS(10)
In Vivo Contraceptive Efficacy of WHI-07 Because fertilization in vivo is dependent on successful sperm transport through the female genital tract, we next determined whether exposure of sperm to the...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: RESULTS(11)
The cervicovaginal region consisted of a stratified squamous epithelium overlying a vascular submucosa. The thickness of the epithelium varied depending on the stage of the estrous cycle. Similar to...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: DISCUSSION(1)
The development of a new class of aryl phosphate derivatives of bromo-methoxy-AZT as dual-function spermicides with potent anti-HIV activity was reported. CASA based on centroid-derived movement...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: DISCUSSION(2)
Physiological fertilization depends on the ability of the ejaculated sperm to swim, bind the zona pellucida, and penetrate the egg, all of which abilities are primarily dependent on sperm motility. The...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: DISCUSSION(3)
The human sperm-zona recognition and binding assays and the zona-free hamster egg binding and penetration assays are useful in predicting the in vivo fertilizing capacity of human sperm. We...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: DISCUSSION(4)
Fertilization in vivo depends upon successful sperm transport through the female genital tract. Results of our in vivo contraceptive efficacy studies in the mouse model demonstrated that prior exposure...
View ArticleAryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: DISCUSSION(5)
The infiltrating leukocytes were identified to be neutrophils. These histopatho-logical features of N-9 observed in this study are similar to those observed in the rat model. That repetitive...
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